Neuroscience/Neurology

KCC2b Heterozygous Mice

KCC2b (Slc12a5) global knockout heterozygous mice on a C57BL/6J background. The Slc12a5 gene has alternative promoters which produce isoforms starting with exon 1a (5-10% total expression) and exon 1b (90-95% expression). As we targeted exon 1b, the mouse in not a global KO of KCC2 but a hypomorphic mouse, still expressing 5-10% protein. It is a global KCC2b KO mouse. Heterozygous animals develop spontaneous seizures in cages. This increases with age. Their brain is hyperexcitable. Homozygous animals die between P17 due to repeated tonic-cloning seizures.

Summary

KCC2b (Slc12a5) global knockout heterozygous mice on a C57BL/6J background.

Licensing manager: 
Jody Hankins
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GluN2B Floxed Mice (also called NR2B, glutamate receptor 2B)

Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background
Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages.  C57BL6/J background.
Licensing manager: 
Jody Hankins
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Inhibitors of Inward-rectifying potassium channels (insecticide)

This research targets IRK.
Licensing manager: 
Tom Utley
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Cell line with stable expression of mutant human voltage gated sodium channel 1.1 (R1648H)

This research targets Nav1.1.
Licensing manager: 
Karen Rufus
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HEK293 cell line with stable expression of drosophila serotonin re-uptake transporter

This research targets SERT.
Licensing manager: 
Karen Rufus
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Rat metabotropic glutamate receptor-7/Galpha15 expressing cell line

This research targets mGLUR7.
Licensing manager: 
Tom Utley
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HEK-293 cell line overexpressing neuronal potassium chloride cotransporter

KCC2 is a neuronal-specific K-CI cotransporter which plays a major role in maintaining intracellular Cl- concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses.

KCC2 is a neuronal-specific K-CI cotransporter which plays a major role in maintaining intracellular Cl- concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses.

http://www.ncbi.nlm.nih

Licensing manager: 
Jody Hankins
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