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Mice Expressing Homozygous Human SCN5A (the Canonical Cardiac Sodium Channel) for the Study of Long QT Syndrome

Transgenic mice homozygous for the human cardiac sodium channel SCN5A gene (human-SCN5A H/H mice), on a C57 and 129sv background. These mice can be used to study function of the post-depolarization sodium current and gender-dependent long QT-related arrhythmias.

Summary:

Transgenic mice homozygous for the human cardiac sodium channel SCN5A gene (human-SCN5A H/H mice), on a C57 and 129sv background.

Licensing manager: 
Jody Hankins
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Immortalized mouse epididymal epithelial cell lines

These cell lines are useful for studying the regulation of tissue-specific gene expression, and may also be used to identify epididymal-specific transcription factors involved in expression of specific proteins in the epididymis.

Summary

These cell lines are useful for studying the regulation of tissue-specific gene expression, and may also be used to identify epididymal-specific transcription factors involved in expression of specific proteins in the epididymis.

Licensing manager: 
Jody Hankins
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KCC2b Heterozygous Mice

KCC2b (Slc12a5) global knockout heterozygous mice on a C57BL/6J background. The Slc12a5 gene has alternative promoters which produce isoforms starting with exon 1a (5-10% total expression) and exon 1b (90-95% expression). As we targeted exon 1b, the mouse in not a global KO of KCC2 but a hypomorphic mouse, still expressing 5-10% protein. It is a global KCC2b KO mouse. Heterozygous animals develop spontaneous seizures in cages. This increases with age. Their brain is hyperexcitable. Homozygous animals die between P17 due to repeated tonic-cloning seizures.

Summary

KCC2b (Slc12a5) global knockout heterozygous mice on a C57BL/6J background.

Licensing manager: 
Jody Hankins
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TagDock:an efficient rigid body molecular docking algorithm for three dimensional models of oligomeric biomolecular complexes with limited experimental restraint data

TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through distance difference analysis TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models

What is TagDock?
TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations.

Licensing manager: 
Masood Machingal
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GluN2B Floxed Mice (also called NR2B, glutamate receptor 2B)

Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background
Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages.  C57BL6/J background.
Licensing manager: 
Jody Hankins
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Tools for targeting and assessing force generation in kinesins

Kinesins are motor proteins in eukaryotic cells powered by ATP hydrolysis. These proteins are involved in various cellular functions including cell division. In particular, Kinesin-5 (also known as KIF11 and Eg5) is essential to forming the microtubule spindle structure in mitosis; therefore, this protein is a potential target for chemotherapeutics. Chimeric kinesin proteins, comprising one or more regions from at least two kinesin proteins, are valuable tools to study the molecular mechanism of kinesin function as well as to identify agents that affect kinesin motor function.
Licensing manager: 
Tom Utley
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Metabolic Labeling Reagents for Chondroitin Sulfate

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans. These stunning images demonstrate incorporation of these metabolic labeling reagents to track neurodevelopmental processes in a zebrafish model system. Notably, the metabolic label can be detected post vivo using a standard "click" chemistry reaction. Further, Dr. Page-McCaw has optimized a background reduction strategy to complement this technology by improving the signal-to-noise ratio.

Summary

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans.

Licensing manager: 
Mike Villalobos
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Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

Summary
A research team at Vanderbilt University Mass Spectrometry Research Center has developed the Molecular Image Fusion software system, that by fusing spatial correspondence between histology and imaging mass spectrometry (IMS) measurements and cross-modality modeling, can predict ion distributions in tissue at spatial resolutions that exceed

Licensing manager: 
Hassan Naqvi
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HCC2429 Human Lung Cancer Cell Line

This research targets HCC2429.
Licensing manager: 
Karen Rufus
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Primary human fibroblats derived from prostate cancer tissue and normal tissue

This research targets prostate cancer.
Licensing manager: 
Karen Rufus
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