Medical Imaging

medical-imaging

Assessment of Right Ventricular Function Using Contrast Echocardiography

Vanderbilt Medical Center researchers have developed a non-invasive and reproducible method of assessing right-ventricular function using contrast-echocardiography. The right-ventricular transit time (RVTT) measures the time needed for echocardiographic contrast to travel from the RV to the bifurcation of the main pulmonary artery. Coupled with the pulmonary transit time (PTT), the time needed for contrast to traverse the entire pulmonary circulation, RVTT is part of a family of diagnostic parameters that can report on RV-specific performance as well as the RV's function relative to that of the pulmonary circuit as a whole.

Summary
Vanderbilt Medical Center researchers have developed a non-invasive and reproducible method of assessing right-ventricular function using contrast-echocardiography. The right-ventricular transit time (RVTT) measures the time needed for echocardiographic contrast to travel from the RV to the bifurcation of the main pulmonary artery.

Licensing manager: 
Chris Harris
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Diamond Field-Emission Cathodes and Channeling Radiation System for High-Brightness X-ray Sources for Phase Contrast Soft Tissue Imaging

The technology disclosed is an electron gun system that comprises an array of gated field-emitting cathode tips having a diamond pyramid capable of producing an electron beam with exquisitely small emittance (N ~ 2 nm); an accelerator capable of accelerating the emitted electrons to relativistic energies (from ~ 3 Mev to~ 50MeV); and a focusing assembly capable of focusing the accelerated electrons into a focal spot on a diamond crystal to produce hard X-rays. Inventors have observed more than 10 mA average current from a single field-emitting tip with improved performance expected with changes to other system components. By using a single tip it may be possible to improve the transverse brightness of the electron beam by as much as six orders of magnitude, with a corresponding improvement of the spectral brilliance of the X-ray beam.

Description of Technology
Conventional X-ray sources are the result of a century’s worth of engineering improvements to the original Crookes tube used by Roentgen. Conventional X-ray systems have insufficient spectral brilliance to perform phase-contrast soft tissue imaging.

Licensing manager: 
Chris Harris
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COX2 Probes for Multimodal Imaging

Inventors at Vanderbilt University have developed a novel chemical design and synthesis process for azulene-based COX2 contrast agents which can be used for molecular imaging, via a variety of imaging techniques. These COX2 probes can be utilized for numerous applications, including imaging cancers and inflammation caused by arthritis and cardiovascular diseases. The process for developing these COX2 contrast agents has been significantly improved through a convergent synthesis process which reduces the required steps to establish the COX2 precursors.

Summary

Inventors at Vanderbilt University have developed a novel chemical design and synthesis process for azulene-based COX2 contrast agents which can be used for molecular imaging, via a variety of imaging techniques.

Licensing manager: 
Ashok Choudhury
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Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

Summary
A research team at Vanderbilt University Mass Spectrometry Research Center has developed the Molecular Image Fusion software system, that by fusing spatial correspondence between histology and imaging mass spectrometry (IMS) measurements and cross-modality modeling, can predict ion distributions in tissue at spatial resolutions that exceed

Licensing manager: 
Hassan Naqvi
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Hyper-SHIELDED - Preserving Parahydrogen Spin Order by Efficient Transfer of Nuclear Singlet

Hyperpolarization of nuclear spin ensembles has increased NMR sensitivity to a level that is now enabling detection of metabolism in biological tissue on a time-scale of seconds. The present invention is a pulse sequence that efficiently transforms parahydrogen spin order into heteronuclear magnetization. This was achieved via a single streamlined sequence without recursive application, by finding sequential analytic solutions to the density matrix evolution for each of four independent intervals that collectively flank two proton inversions and one heteronuclear excitation. The name hyper-SHIELDED (Singlet to Heteronuclei by Interative Evolution Locks Dramatic Enhancement for Delivery) reflects the sequence's protective effect on PHIP hyperpolarization.

Description of Technology

Hyperpolarization of nuclear spin ensembles has increased NMR sensitivity to a level that is now enabling detection of metabolism in biological tissue on a time-scale of seconds.

Licensing manager: 
Chris Harris
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PANORAMIC: Precession and Nutation for Observing Rotation at Multiple Intervals about the Carrier

Methods of hyperpolarization based on parahydrogen have been expanding recently from the early applications in hydrogenation chemistry to biomedical imaging where they are expected to yield similar information as the competing technology, dynamic nuclear polarization, (DNP). These hyperpolarization experiments have already enabled the measurement of metabolism in vivo at temporal resolutions of seconds. When infused into organisms harboring tumor cells, molecules such as pyruvate and lactate have been shown to be sufficiently long-lived to infiltrate cellular metabolic cycles and be converted at different rates in cancer versus normal tissue. DNP has been used most frequently in these early studies, owing to commercial availability and the flexibility to polarize small molecules such as pyruvate and lactate. Techniques based on chemical addition or exchange of parahydrogen have also shown promise for generating metabolic contrast in vivo at similar levels of signal enhancement and at lower costs.

Summary

Methods of hyperpolarization based on parahydrogen have been ex

Licensing manager: 
Chris Harris
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Parahydrogen-Induced Polarizer (PHIP)

The present invention provides a PANACEA (Pneumatics Allow Nonmagnetic Actuation for Creation of Enhanced Alignment) polarizer system. This is an integrated assembly of pneumatically actuated, nonmagnetic hydraulic circuits that enable PASADENA chemicals to be efficiently stored, mixed, and reacted in close proximity or within NMR magnetic fields.

Summary

The hear

Licensing manager: 
Chris Harris
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Chemical Synthesis of Isotopically Enriched Unsaturated Precursors for Parahydrogen Induced Polarization of 15N Hyperpolarized Choline

The present invention provides unsaturated choline analogs which, when hyperpolarized, may be useful as MRI contrast agents, and methods of making these choline analogs. These analogs can also be further modified to form hyperpolarized choline for use as an MRI contrast agent. The invention takes advantage of PHIP and can be produced in volume in much shorter times than by using DNP.

Summary

Hyperpolarized MRI offers a sensitivity increase by 4-6 orders

Licensing manager: 
Chris Harris
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Relaxation Time Discriminated 1H NMR for Bone Mechanical/Fracture Property Diagnostics

The present invention describes clinically-practical MRI methods for distinguishing bound and pore water signals from cortical bone based on T2-selective adiabatic pulses as well as T1 characteristics of cortical bone bound and pore water, and offers an improved method of assessing bone structure and fracture risk over x-ray based diagnostic techniques.

Technology Description

Advances in modern MRI pulse sequences have enab

Licensing manager: 
Chris Harris
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Simultaneous RNA and Gene Expression Profiling Using Mass Spectrometry

This technology allows the simultaneous detection of RNA transcript abundance (as an assay of gene expression) and protein abundance (as an assay of protein expression) from biological samples without RNA isolation, labeling or amplification. Existing technologies allow for very efficient determinations of protein abundance from a wide variety of biological samples. These methods are in widespread use and are based on mass spectrometry technologies. There are no available technologies that allow efficient and quantitative assessment of multiple RNA transcripts without a previous isolation followed by labeling and/or amplification. The most efficient technologies currently available make use of DNA microarrays to profile RNA abundance as a measure of gene expression. While very robust and useful, these technologies are very labor intensive and suffer from a number of technological drawbacks. This technology takes advantage of a number of existing methods and techniques and brings them together in a novel manner that greatly expands the state of the art for gene expression.

Summary

This technology allows the simultaneous detection of RNA transcript abundance (as an assay of gene expression) and protein abundance (as an assay of protein expression) from biological samples without RNA isolation, labeling or amplification.

Licensing manager: 
Hassan Naqvi
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