Diagnostics

diagnostics

Assessment of Right Ventricular Function Using Contrast Echocardiography

Vanderbilt Medical Center researchers have developed a non-invasive and reproducible method of assessing right-ventricular function using contrast-echocardiography. The right-ventricular transit time (RVTT) measures the time needed for echocardiographic contrast to travel from the RV to the bifurcation of the main pulmonary artery. Coupled with the pulmonary transit time (PTT), the time needed for contrast to traverse the entire pulmonary circulation, RVTT is part of a family of diagnostic parameters that can report on RV-specific performance as well as the RV's function relative to that of the pulmonary circuit as a whole.

Summary
Vanderbilt Medical Center researchers have developed a non-invasive and reproducible method of assessing right-ventricular function using contrast-echocardiography. The right-ventricular transit time (RVTT) measures the time needed for echocardiographic contrast to travel from the RV to the bifurcation of the main pulmonary artery.

Licensing manager: 
Chris Harris
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Diagnostic to Predict Paternal Premature Birth Risk Factors: Therapy Can Reduce Risk

Premature birth is the leading cause of neonatal death worldwide, affecting 13% of US infants (500,000 babies/year). Of great concern, premature birth cannot currently be reliably predicted or prevented. Existing risk factors and interventions for premature birth focus solely on maternal factors, thereby overlooking paternal factors that influence an infant's development. Vanderbilt researchers have now identified a missing piece of the puzzle and are developing a diagnostic test to predict premature birth risks conferred to infants by their fathers. Of key importance, the test offers meaningful clinical guidance, as risk factors measured by the diagnostic can be modified before conception via supplementation.

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Licensing manager: 
Hassan Naqvi
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Prognostic Test Identifies Infants at High-Risk for Severe Respiratory Infection

Dr. Fernando P. Polack, a leading international researcher in pediatric infectious diseases, has discovered a new prognostic to predict which infants are at high-risk for hospitalization caused by severe Respiratory Syncytial Virus (RSV) infections. The test measures a mutation in a single gene, along with a quantifiable environmental factor that confers susceptibility. The goal is to categorize infants most likely to benefit from preventative care.

Mike Villalobos
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Colorectal Cancer Risk Screening Assay

The overall lifetime colorectal cancer risk for Americans is 5.1%, thus screening is recommended for those over the age of 50. Currently, colonoscopies are the standard for monitoring colon cancer development, but are invasive. Therefore, a need exists for a minimally-invasive test that could measure colon cancer risk. Ideally, such a test would offer a straightforward, personalized recommendation on how to substantially reduce colorectal cancer risk. Researchers at Vanderbilt University have identified a test that can characterize colorectal cancer risk and recommend a strategy for risk reduction. Importantly, this test requires only a blood sample and information about a person's diet.

The Problem

The overall lifetime colorectal cancer risk for Americans is 5.1%, thus screening is recommended for those over the age of 50. Currently, colonoscopies are the standard for monitoring colon cancer development, but are invasive.

Licensing manager: 
Mike Villalobos
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Gene Signature Diagnostic to Measure LKB1 Loss and MEK Inhibitor Sensitivity

A Vanderbilt research group has discovered a diagnostic to identify patients with non-small cell lung cancer that would respond to MEK inhibitor therapies. This diagnostic indirectly measures loss of tumor suppressor activity by the protein LKB1. The traditional approach to determine MEK inhibitor sensitivity, which is measurement of LKB1 mutations, misses 50% of patients who would benefit from these drugs. This diagnostic measures expression of a small panel of genes to identify a larger population that is sensitive to MEK inhibition.

Description of Technology

A Vanderbilt research group has discovered a diagnostic to identify patients with non-small cell lung cancer that would respond to MEK inhibitor therapies.

Licensing manager: 
Mike Villalobos
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Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

Summary
A research team at Vanderbilt University Mass Spectrometry Research Center has developed the Molecular Image Fusion software system, that by fusing spatial correspondence between histology and imaging mass spectrometry (IMS) measurements and cross-modality modeling, can predict ion distributions in tissue at spatial resolutions that exceed

Licensing manager: 
Hassan Naqvi
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Slot-Slot Assay for Malonaldehyde-Deoxyguanosine Adducts in DNA

This research targets DNA adducts.
Licensing manager: 
Mike Villalobos
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Method for extracting molecules from tissues

This research targets molecular extraction.
Licensing manager: 
Hassan Naqvi
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Diagnostics Management Team

The sheer volume of medical information available to physicians today is overwhelming. Diagnostic Management Team provides a concise, accurate method for ordering the correct diagnostic tests every time, and it returns the results in a uniform report format, easily read by the physician. This has already been launched within Vanderbilt University, with a high adoption rate amongst physicians and has already shown significant savings.
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Licensing manager: 
Hassan Naqvi
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Relaxation Time Discriminated 1H NMR for Bone Mechanical/Fracture Property Diagnostics

The present invention describes clinically-practical MRI methods for distinguishing bound and pore water signals from cortical bone based on T2-selective adiabatic pulses as well as T1 characteristics of cortical bone bound and pore water, and offers an improved method of assessing bone structure and fracture risk over x-ray based diagnostic techniques.

Technology Description

Advances in modern MRI pulse sequences have enab

Licensing manager: 
Chris Harris
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