Past Chemical-Biology Interface Trainees

2010

Jonas Perez
Advisor: David Wright
Current Position: Law School

Thomas Tomasiak
Advisor: Tina Iverson
Current Position: PostDoc, University of California-San Francisco

Kevin Oliver
Masters in Chemistry, 2010
Advisor: Gary Sulikowki
Current Position: Associate Chemist, Color Corporation of America, KY

2009

Chinessa Adkins
Ph.D. in Chemistry, 2009
Advisor: Eva Harth
Current Position: Postdoctoral Fellow, Howard Hughes Medical Institute, Chevy Chase, MD

Chinessa Adkins Publications

Adkins, C. T.; Harth, E., Synthesis of star polymer architectures with site-isolated chromophore cores. Macromolecules 2008, 41 (10), 3472-3480.

Adkins, C. T.; Muchalski, H.; Harth, E., Nanoparticles with Individual Site-Isolated Semiconducting Polymers from Intramolecular Chain Collapse Processes. Macromolecules 2009, 42 (15), 5786-5792.

Croce, T. A.; Funk, M.; Adkins, C. T.; Harth, E., Strategies and synthesis of suitable precursors for the construction of 3-D bioactive scaffolds. Abstracts of Papers of the American Chemical Society 2005, 230, 337-PMSE.

Croce, T. A.; Muchalski, H.; Adkins, C. T.; Huang, K.; Hamilton, S. K.; van der Ende, A.; Harth, E., Approaches in the development of 3-D nanoscopic, multifunctional vectors. Abstracts of Papers of the American Chemical Society 2006, 231, 171-PMSE.

Somarajan, S.; Hasan, S. A.; Adkins, C. T.; Harth, E.; Dickerson, J. H., Controlled electrophoretic deposition of uniquely nanostructured star polymer films. Journal of Physical Chemistry B 2008, 112 (1), 23-28.

Amanda Kussrow
Ph. D. in Chemistry, 2009
Advisor: Darryl Bornhop
Current Position: Postdoctoral Researcher, Dr. M. C. Finn and Dr. Darryl Bornhop, Vanderbilt University

Amanda Kussrow Publications

Bornhop, D. J.; Latham, J. C.; Kussrow, A.; Markov, D. A.; Jones, R. D.; Sorensen, H. S., Free-solution, label-free molecular interactions studied by back-scattering interferometry. Science 2007, 317 (5845), 1732-1736.

Kussrow, A.; Kaltgrad, E.; Wolfenden, M. L.; Cloninger, M. J.; Finn, M. G.; Bornhop, D. J., Measurement of Monovalent and Polyvalent Carbohydrate-Lectin Binding by Back-Scattering Interferometry. Analytical Chemistry 2009, 81 (12), 4889-4897.

2008

Almary Chacon
Ph.D. in Chemistry, 2008
Advisor: Ned Porter
Current Position: Research Fellow with John Oates and Richard Caprioli, Vanderbilt University

Almary Chacon Publications

Chacon, A.; Masterson, D. S.; Yin, H. Y.; Liebler, D. C.; Porter, N. A., N-terminal amino acid side-chain cleavage of chemically modified peptides in the gas phase: A mass spectrometry technique for N-terminus identification. Bioorganic & Medicinal Chemistry 2006, 14 (18), 6213-6222.

Masterson, D. S.; Yin, H. Y.; Chacon, A.; Hachey, D. L.; Norris, J. L.; Porter, N. A., Lysine peroxycarbamates: Free radical-promoted peptide cleavage. Journal of the American Chemical Society 2004, 126 (3), 720-721.

Yin, H.; Chacon, A.; Porter, N. A.; Yin, H. Y.; Masterson, D. S., Free radical-induced site-specific peptide cleavage in the gas phase: Low-energy collision-induced dissociation in ESI- and MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry 2007, 18 (5), 807-816.

Andrew Felts
Ph.D. in Chemistry, 2008
Advisor: Larry Marnett
Current Position: Senior Research Specialist with Craig Lindsley, Vanderbilt University

Andrew Felts Publications

Ansari, M. S.; Jones, C. K.; Felts, A. S.; Lindsley, C. W.; Alagille, D.; Tamagnan, G. D.; Kessler, R. M.; Baldwin, R. M., ONE POT SYNTHESIS OF 18F FPEB IN A SEMI-AUTOMATED MODULE. Journal of Labelled Compounds & Radiopharmaceuticals 2009, 52, S318-S318. Felts, A. S., Molecule of the month. Current Topics in Medicinal Chemistry 2008, 8 (14), 1310-1310.

Felts, A. S.; Ji, C.; Stafford, J. B.; Crews, B. C.; Kingsley, P. J.; Rouzer, C. A.; Washington, M. K.; Subbaramaiah, K.; Siegel, B. S.; Young, S. M.; Dannenberg, A. J.; Marnett, L. J., Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology. Acs Chemical Biology 2007, 2 (7), 479-483.

Felts, A. S.; Siegel, B. S.; Young, S. M.; Moth, C. W.; Lybrand, T. P.; Dannenberg, A. J.; Marnett, L. J.; Subbaramaiah, K., Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition. Journal of Medicinal Chemistry 2008, 51 (16), 4911-4919.

Felts, A.; Ji, C.; Prusakiewicz, J.; Mackenzie, B.; Crews, B.; Marnett, L. J. In Design and synthesis of indomethacin and sulindac derivatives that induce tumor cell apoptosis but do not inhibit cyclooxygenases, Elsevier Science Inc: 2006; pp 161-161.

Felts, A. S.; Ji, C.; Prusakiewicz, J. J.; Marnett, L. J., Structure-based design of novel NSAIDs that induce apoptosis in tumor cells but lack COX-2 inhibitory activity. Proceedings of the American Association for Cancer Research Annual Meeting 2005, 46, 595.

Marnett, L. J.; Prusakiewicz, J. J.; Felts, A. S.; Ji, C. Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity. US 07491744, Feb 10 2009, 2009.

Walters, M. J.; Blobaum, A. L.; Kingsley, P. J.; Felts, A. S.; Sulikowski, G. A.; Marnett, L. J., The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. Bioorganic & Medicinal Chemistry Letters 2009, 19 (12), 3271-3274.

Craig Garmendia
Masters in Chemistry, 2008
Advisor: Carmelo J. Rizzo
Current Position: Chemist, USDA, Miami FL

Craig Garemendia Publications

Christov, P. P; Chowdhury, G.; Garmendia, C. A.; Wang, F.; Stover, J. S.; Elmquist, C. E.; Kozekova, A.; Angel K. C.; Turesky, R. J.; Stone, M. P.; Guengerich, F. P.; Rizzo, C. J., The C8-2′-Deoxyguanosine Adduct of 2-Amino-3-methylimidazo[1,2-d]naphthalene, a Carbocyclic Analogue of the Potent Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline, Is a Block to Replication in Vitro. Chemical Research in Toxicology 2010, 23 (6) 1076-108.

Christopher Moth
Ph.D. in Chemistry, 2008
Advisor: Terry Lybrand

Chris Moth Publications

Moth, C. W.; Prusakiewicz, J. E. J.; Marnett, L. J.; Lybrand, T. P., Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1. Journal of Medicinal Chemistry 2005, 48 (10), 3613-3620.

Ioanna Ntai
Ph.D. in Chemistry, 2008
Advisor: Brian Bachmann
Current Position: Post-Doctoral Research with Neil Kelleher, University of Illinois

Ionna Ntai Publications

Ghidu, V. P.; Ntai, I.; Wang, J. Q.; Jacobs, A. T.; Marnett, L. J.; Bachmann, B. O.; Sulikowski, G. A., Combined Chemical and Biosynthetic Route to Access a New Apoptolidin Congener. Organic Letters 2009, 11 (14), 3032-3034.

Ntai, I.; Bachmann, B. O. In Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26, Pergamon-Elsevier Science Ltd: 2008; pp 3068-3071.

Ntai, I.; Manier, M. L.; Hachey, D. L.; Bachmann, B. O., Biosynthetic origins of C-P bond containing tripeptide K-26. Organic Letters 2005, 7 (13), 2763-2765.

Ntai, I.; Phelan, V. V.; Bachmann, B. O., Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis. Chemical Communications 2006, (43), 4518-4520.

Hu, Y. F.; Phelan, V.; Ntai, I.; Famet, C. M.; Zazopoulos, E.; Bachmann, B. O., Benzodiazepine biosynthesis in Streptomyces refuineus (vol 14, pg 691, 2007). Chemistry & Biology 2007, 14 (7), 870-870.

Hu, Y.; Phelan, V.; Ntai, I.; Farnet, C. M.; Zazopoulos, E.; Bachmann, B. O., Benzodiazepine biosynthesis in Streptomyces refuineus. Chemistry & Biology 2007, 14 (6), 691-701.

Rachel Snider
Ph.D. in Chemistry, 2008
Advisor: David Cliffel
Current Position: Postdoctoral Associate, Naval Research Laboratory (NRL)

Rachel Snider Publications

Cliffel, D. E.; Eklund, S.; Snider, R., Cell-based detection of biological toxins using metabolic microphysiometry. Abstracts of Papers of the American Chemical Society 2006, 231, 396-ANYL.

Cliffel, D. E.; Eklund, S.; Snider, R., Cell-based detection of biological toxins using metabolic microphysiometry. Abstracts of Papers American Chemical Society 2006, 231, 396-ANYL.

Eklund, S. E.; Snider, R. M.; Wikswo, J.; Baudenbacher, F.; Prokop, A.; Cliffel, D. E., Multianalyte microphysiometry as a tool in metabolomics and systems biology. Journal of Electroanalytical Chemistry 2006, 587 (2), 333-339.

Eklund, S. E.; Thompson, R. G.; Snider, R. M.; Carney, C. K.; Wright, D. W.; Wikswo, J.; Cliffel, D. E., Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer. Sensors 2009, 9 (3), 2117-2133.

Snider, R. M.; Ciobanu, M.; Rue, A. E.; Cliffel, D. E., A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber. Analytica Chimica Acta 2008, 609 (1), 44-52.

Melissa Vaught Turman
Ph.D. in Chemistry, 2008
Advisor: Larry Marnett
Current Position: Postdoctoral Researcher with M. Carrol, Harvard Medical School

Melissa Vaught Turman Publications

Turman, M. V.; Kingsley, P. J.; Rouzer, C. A.; Cravatt, B. F.; Marnett, L. J., Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine. Biochemistry 2008, 47 (12), 3917-3925.

Turman, M. V.; Kinsgley, P. J.; Marnett, L. J., Cyclooxygenase-2-dependent oxygenation of N-(3-hydroxyphenyl) arachidonylamide, an irreversible and selective inactivator of cyclooxygenase-2. Prostaglandins & Other Lipid Mediators 2006, 79 (1-2), 186-186.

Harman, C. A.; Turman, M. V.; Kozak, K. R.; Marnett, L. J.; Smith, W. L.; Garavito, R. M., Sturctural basis of enantioselective inhibition of cyclooxygenase-1 S-alpha-Substituted indomethacin ethanolamides. Journal of Biological Chemistry 2007, 282, 28096-28105.

Prusakiewicz, J. J.; Turman, M. V.; Vila, A.; Ball, H. L.; Al-Mestarihi, A. H.; Di Marzo, V.; Marnett, L. J., Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases. Archives of Biochemistry and Biophysics 2007, 464 (2), 260-268.

2007

Aren Gerdon
Ph.D. in Chemistry, 2007
Advisor: David Cliffel
Current Position: Assistant Professor of Chemistry, Emmanuel University

Aren Gerdon Publications

Gerdon, A. E.; Huffman, B. J.; Wright, D. W.; Cliffel, D. E. In Detection of Ebola glycoprotein using quartz crystal microbalance immunosensor, Amer Chemical Soc: 2006; pp 1-IEC.

Gerdon, A. E.; Wright, D. W.; Cliffel, D. E., Hemagglutinin linear epitope presentation on monolayer-protected clusters elicits strong antibody binding. Biomacromolecules 2005, 6 (6), 3419-3424.

Gerdon, A. E.; Wright, D. W.; Cliffel, D. E., Quartz crystal microbalance detection of glutathione-protected nanoclusters using antibody recognition. Analytical Chemistry 2005, 77 (1), 304-310.

Gerdon, A. E.; Wright, D. W.; Cliffel, D. E., Epitope mapping of the protective antigen of B-anthracis by using nanoclusters presenting conformational peptide epitopes. Angewandte Chemie-International Edition 2006, 45 (4), 594-598.

Gerdon, A. E.; Wright, D. W.; Cliffel, D. E.; Mernaugh, R. In Confirmed binding of single chain (SCFV) recombinant antibodies to zero valent metals with quartz crystal microbalance, Amer Chemical Soc: 2004; pp 980-INOR.

Gerdon, A. E.; Huffman, B. J.; Wright, D. W.; Cliffel, D. E., Detection of Ebola glycoprotein using quartz crystal microbalance immunosensor. Abstracts of Papers American Chemical Society 2006, 231, 1-IEC.

Gerdon, A. E.; Wright, D. W.; Cliffel, D. E.; Mernaugh, R., Confirmed binding of single chain (SCFV) recombinant antibodies to zero valent metals with quartz crystal microbalance. Abstracts of Papers American Chemical Society 2004, 227 (Part 1), U1559.

Gies, A. P.; Hercules, D. M.; Gerdon, A. E.; Cliffel, D. E., Electrospray mass spectrometry study of tiopronin monolayer-protected gold nanoclusters. Journal of the American Chemical Society 2007, 129 (5), 1095-1104.

Yu, J. S.; Liao, H. X.; Gerdon, A. E.; Huffman, B.; Scearce, R. M.; McAdams, M.; Alam, S. M.; Popernack, P. M.; Sullivan, N. J.; Wright, D.; Cliffel, D. E.; Nabel, G. J.; Haynes, B. F., Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor. Journal of Virological Methods 2006, 137 (2), 219-228.

Deravi, L. F.; Gerdon, A. E.; Cliffel, D. E.; Wright, D. W.; Sumerel, J. L., Output analysis of materials inkjet printer. Applied Physics Letters 2007, 91 (11), 3.

2005

Lindsay Frilling
M.S. in Chemistry, 2005
Advisor: Brian O. Bachmann
Current Position: Research Associate at Givaudan Flavors Corporation

Rachel Pharris-Rigsby
Ph.D. in Chemistry, 2005
Advisor: Richard N. Armstrong
Current Position: Assistant Professor of Chemistry, Belmont University

Rachel Pharris-Rigsby Publications

Rigsby, R. E.; Brown, D. W.; Dawson, E.; Lybrand, T. P.; Armstrong, R. N., A model for glutathione binding and activation in the fosfomycin resistance protein, FosA. Archives of Biochemistry and Biophysics 2007, 464 (2), 277-283.

Rigsby, R. E.; Fillgrove, K. L.; Beihoffer, L. A.; Armstrong, R. N., Fosfomycin resistance proteins: A nexus of glutathione transferases and epoxide hydrolases in a metalloenzyme superfamily. In Gluthione Transferases and Gamma-Glutamyl Transpeptidases, Elsevier Academic Press Inc: San Diego, 2005; Vol. 401, pp 367-379.