Current Research Targets
The overreaching goal of our research is the development of versatile platforms of innovative vectors for cancer therapeutics, vaccine development and imaging reagents in nanomedicine. With the growing sophistication of polymerization strategies, the implementation of functionality and utilization of macromolecular architectures will be key for many of the promising applications in nanotechnology related to the biomedical field and materials science. Thereby structural and functional fidelity compatible for bioconjugation is a focus in the design of the polymer topology.
1.) Design of degradable “Nanosponges” for Treatment and Imaging. Novel 3-D nano networks, “nanosponges” can be tailored in their size, linear release profile of drugs and are easily functionalized with targeting units and cell penetrating units such as the molecular transporter.
Drug molecules can be encapsulated to up to 20% with hydrophobic drug molecules and peptides and the delivery systems are well dispersed in aqueous solutions for IV injections.
Preliminary in vivo data have indicated significantly increased efficacy of these delivery systems in treatment of cancer and eye diseases.
2.) A new Generation of Molecular Transporter. Considering the low efficiency of cellular transport, we investigate dendritic molecular transporter of unique design to allow the delivery of bioactive cargos specifically to the cytosol or nucleus without unwanted intracellular probe metabolism and transport.
The systemic combination of nanovectors with preferred therapeutics, targeting moieties and vectors for cellular uptake provides the opportunity to obtain a large number of personalized therapeutic reagents.
3.) Towards organic ‘quantum dots- Approaches to novel semiconducting Nanoparticles. In demand of imaging probes correlated with the efficacy of drug carriers, well-defined nanoparticles are developed for in vivo imaging and device technologies. They contain fluorescent core units and are decorated with lanthanides to provide powerful bimodal imaging reagents and will vitalize the investigation of electronic properties through site-isolation effects of electroactive entities in well-defined nanoobjects.