Sulikowski Research

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“In vitro and in vivo studies of the antiparasitic activity of sterol 14alpha-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi” M. de Nazare Correia Soeiro, E. Mello de Souza, C. Franca da Silva, D. da Gama Jaen Batista, M. Meuser Batista, B. Philot Pavao, J. Siciliano Araujo, C. Alessandra Fortes Aiub, P. Bernardino da Silva, J. Lionel, C. Britto, K. Kim, G. A. Sulikowski, T. Y. Hargrove, M. R. Waterman, G. I. Lepesheva Antimicrobial Agents and Chemotherapy, 2013, 57, 4151-4163. doi: 10.1128/AAC.00070-13.



“Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus” M. K. Thompson, M. E. Keithly, J. Harp, P. D. Cook, K. L. Jagessr, G. A. Sulikowski, R. N. Armstrong Biochemistry, 2013, 52, 7350-7362. doi:    10.1021/bi4009648.



“ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice” K. Kaufmann, I. M. Romaine, E. Days, C. Pascual, A. Malik, L. Yang, B. Zou, Y. Du, G. Sliwoski, R. D. Morrison, J. Denton, C. M. Niswender, J. S. Daniel, G. A. Sulikowski, X. Xie, C. W. Lindsley, C. D. Weaver ACS Chemical Neuroscience, 2013, 4, 1278-1286. doi: 10.1021/cn400062a.



“Discovery and SAR of a novel series of GIRK 1/2 and GIRK 1/4 activators” S. J. Ramos-Hunter, D. W. Engers, K. Kaufmann, Y. Du, C. W. Lindsley, C. D. Weaver, G. A. Sulikowski Bioorg. Med. Chem. Lett., 2013, 23, 5195-5198. doi: 10.1016/j.bmcl.2013.07.002.



“Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors” W. D. Wen, W. J. Wu, I. M. Romaine, K. Kaufmann, Y. Du, G. A. Sulikowski, C. D. Weaver, C. W. Lindsley Bioorg. Med. Chem. Lett., 2013, 23, 4562-4566. doi: 10.1016/j.bmcl.2013.06.023.



“Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus” L. A. Mike, B. F. Dutter, D. L. Stauff, J. L. Moore, N. P. Vitko, O. Aranmolate, T. E. Kehl-Fie, S. Sullivan, P. R. Reid, J. L. DuBois, A. R. Richardson, R. M. Caprioli, G. A. Sulikowski, E. P. Skaar PNAS, 2013, 110, 8206-8211. doi: 10.1073/pnas.1303674110



“Straightforward protocol for the efficient synthesis of varied N’-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up” A. J. Liedtke, K. Kim, D. F. Stec, G. A. Sulikowski, L. J. Marnett Tetrahedron, 2012, 68, 10049-10058. doi: 10.1016/j.tet.2012.08.044



“Structure-Activity Relationship of a Broad-Spectrum Odorant Receptor Agonist” R. W. Taylor, I. M. Romaine, C. Liu, P. Murthi, P. L. Jones, A. G. Waterson, G. A. Sulikowski, L. J. Zwiebel ACS Chem. Bio., 2012, 7, 1647-1652.  doi:  10.1021/cb300331z



“Synthesis of Bacillithiol and the Catalytic Selectivity of FosB-Type Fosfomycin Resistance Proteins” A. P. Lamers, M. E. Keithly, K. Kim, P. D. Cook, D. F. Stec, K. M. Hines, G. A. Sulikowski, R. N. Armstrong Org. Lett, 2012, 14, 5207-5209.  doi:  10.1021/ol302327t



“Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN probe ML012” B. J. Melancon, A. P. Lamers, T. M. Bridges, G. A. Sulikowski, T. J. Utley, D. J. Sheffler, M. J. Noetzel, R. D. Morrison, J. S. Daniels, C. M. Niswender, C. K. Jones, P. J. Conn, C. W. Lindsley, M. R. Wood  Bioorg. Med. Chem. Lett. 2012, 22, 1044-1048. 

doi:  10.1016/j.bmcl.2011.11.110



“Synthetic Studies Directed Toward Dideoxy Lomaiviticinone Lead to Unexpected 1,2-Oxazepine and Isoxazole Formation” A. Baranczak, G. A. Sulikowski  Org. Lett. 2012, 14, 1027-1029.  doi:  10.1021/ol203390w



“Allosteric Antagonism of Insect Odorant Receptor Ion Channels” P. L. Jones, G. M. Pask, I. M. Romaine, R. W. Taylor, P. R. Reid, A. G. Waterson, G. A. Sulikowski, L. J. Zweibel  PLoS ONE 2012, 7(1): e30304.  doi:  10.1371/journal.pone.0030304



“Cascade assembly of the benzo[a]anthraquinone ring system common to the angucycline antibiotics”  A. Baranczak, G. A. Sulikowski  Tet. Lett. 2012, 53, 1345-1346.  doi:  10.1016/j.tetlet.2011.12.126



“Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN probe ML012” B. J. Melancon, A. P. Lamers, T. M. Bridges, G. A. Sulikowski, T. J. Utley, D. J. Sheffler, M. J. Noetzel, R. D. Morrison, J. S. Daniels, C. M. Niswender, C. K. Jones, P. J. Conn, C. W. Lindsley, M. R. Wood Bioorg. Med. Chem. Lett., 2012, 22, 1044-1048.

doi: 10.1016/j.bmcl.2011.11.110



“Synthesis of a Bicyclobutane Fatty Acid Identified from the Cyanobacterium Anabaena PCC 7120”  S. M. DeGuire, S. Ma, G. A. Sulikowski  Angew. Chem. Int. Ed. 2011, 50, 9940-9942.  doi:  10.1002/anie.201104366



“Assignment and Stereocontrol of Hibarimicin Atropoisomers”  I. M. Romaine, J. E. Hempel, G. Shanmugam, H. Hori, Y. Igarashi, P. L. Polavarapu, G. A. Sulikowski  Org. Lett. 2011, 13, 4538-4541.  doi:  10.1021/ol2017005



“Biosynthesis of the apoptolidins in Nocardiopsis sp. FU 40”  Y. Du, D. K. Derewacz, S. M. DeGuire, J. Teske, J. Ravel, G. A. Sulikowski, B. O. Bachmann  Tetrahedron 2011, 67, 35, 6568-6575.  doi:  10.1016/j.tet.2011.05.106



“A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors”  T. Pyburn, B. A. Bensing, Y. Q. Xiong, B. J. Melancon, T. M. Tomasiak, N. J. Ward, V. Yankovskaya, K. M. Oliver, G. Cecchini, G. A. Sulikowski, M. J. Tyska, P. M. Sullam, T. M. Iverson  PLoS Pathogens 2011, 7, 7, e1002112.  doi:  10.1371/journal.ppat.1002112



18O Assisted Analysis of a γ,δ-Epoxyketone Cyclization: Synthesis of the C16-C28 Fragment of Ammocidin D”  S. T. Chau, Y. Hayakawa, G. A. Sulikowski  Org. Lett. 2011, 13, 756-759.  doi:  10.1021/ol103003f



“Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α” C. A. Thorne, A. J. Hanson, J. Schneider, E. Tahinci, D. Orton, C. S. Cselenyi, K. K. Jernigan, K. C. Meyers, B. I. Hang, A. G. Waterson, K. Kim, B. Melancon, V. P. Ghidu, G. A. Sulikowski, B. LaFleur, A. Salic, L. A. Lee, D. M. Miller III, E. Lee  Nat. Chem. Bio. 2010, 6, 829-836.  doi:  10.1038/nchembio.453



“Light-Induced Isomerization of Apoptolidin A leads to Inversion of C2−C3 Double Bond Geometry” B. O. Bachmann, R. McNees, B. J. Melancon, V. P. Ghidu, R. Clark, B. C. Crews, S. M. DeGuire, L. J. Marnett, G. A. Sulikowski  Org. Lett. 2010, 12, 2944-2947. 

doi:  10.1021/ol1009398



“Synthesis and bioactivity of (+)-tetrahydrohaliclonacyclamine A” B. J. Smith, T. Qu, M. Mulder, M. J. Noetzel, C. W. Lindsley, G. A. Sulikowski Tetrahedron 2010, 66, 4805-4810.  doi: 10.1016/j.tet.2010.03.117



“Total Synthesis of (+)-Haliclonacyclamine C“ B. J. Smith and G. A. Sulikowski Angew. Chem. Int. Ed. 2010, 49, 1599-1602. 

doi: 10.1002/anie.200905732



“Progress toward the Total Synthesis of Lucentamycin A: Total Synthesis and Biological Evaluation of 8-epi-Lucentamycin A”  R. N. Daniels, B. J. Melancon, E. A. Wang, B. C. Crews, L. J. Marnett, G. A. Sulikowski and C. W. Lindsley J. Org. Chem. 2009, 74, 8852-8855.  doi: 10.1021/jo902115s



"Combined Chemical and Biosynthetic Route to Access a New Apoptolidin Congener" V. P. Ghidu, I. Ntai, J. Wang, A. T. Jacobs, L. J. Marnett, B. O. Bachmann and G. A. Sulikowski Org. Lett. 2009, 11, 3032-3034.  doi: 10.1021/ol901045v



"The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives" M. J. Walters, A. L. Blobaum, P. J. Kingsley, A. S. Felts, Sulikowski, G. A., L. J. Marnett Bioorg. Med. Chem. Lett. 2009, 19, 3271-3274.

doi: 10.1016/j.bmcl.2009.04.078



"Chirality Relay to Access Oxygenated Angular Aromatic Polyketides" A. Baranczak and G. A. Sulikowski Angew. Chem. Int. Ed. 2009, 48, 6005-6007.  doi: 10.1002/anie.200901712



"Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago-potentiator ADX-47273" D. W. Engers, A. L. Rodriguez, R. Williams, A. S. Hammond, D. Venable, O. Oluwatola, G. A. Sulikowski, P. J. Conn and C. W. Lindsley ChemMedChem 2009, 4, 505-511.  doi: 10.1002/cmdc.200800357



"A New Multi-gram Synthetic Route to Labeling Precursors for the D2/3 PET Agent 18F-Fallypride" K. Kim, N. R. Miller, G. A. Sulikowski and C. W. Lindsley Bioorg. Med. Chem. Lett. 2008, 18, 4467-4469.  doi: 10.1016/j.bmcl.2008.07.065



“Synthesis and Evaluation of the Cytotoxicity of Apoptolidinones A and D” V. P. Ghidu, J. Wang, B. Wu, Q. Liu, A. Jacobs, L. J. Marnett and G. A. Sulikowski J. Org. Chem. 2008, 73, 4949-4955.  doi: 10.1021/jo800545r



“Stereocontrolled Assembly of the C3/C3’ Dideoxy Core of Lomaiviticin A/B and Congeners” W. Zhang, A. Baranczak and G. A. Sulikowski Org. Lett. 2008, 10, 1939-1941.  doi: 10.1021/ol800460a



"Formation of the BC Ring System of Upenamide via a Staudinger/aza-Wittig Reaction" S. Luo, K. Peplowski and G. A. Sulikowski Org. Lett. 2007, 9, 5051-5054.  doi: 10.1021/ol702255k

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