Publications

Publications produced by our group:




In Press











    2014


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      77. Jody C. May, Cody R. Goodwin, Nichole M. Lareau, Katrina L. Leaptrot, Caleb B. Morris, Ruwan Thushara Kurulugama, Alex Mordehai, Christian Klein, William Barry, Ed Darland, Gregor Overney, Kenneth Imatani, George C. Stafford, John C. Fjeldsted, and John A. McLean, Conformational Ordering of Biomolecules in the Gas-Phase: Nitrogen Collision Cross-Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer, Analytical Chemistry 2014. 86 (4): 2107-2116.







2013


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    76. Connor R. Lamberson, Libin Xu, Hubert Muchalski, J. Rafael Montenegro-Burke, Vadim V. Shmanai, Andrei V. Bekish, John A. McLean, Catherine F. Clarke, Mikhail S. Shchepinov, and Ned A. Porter, Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol-Mediated Free Radical Chain Oxidations, Journal of the American Chemical Society 2013. 136 (3): 838-841.





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    75. Donald J. Alcendor, Frank E. Block III, David E. Cliffel, John Scott Daniels, Kate LJ Ellacott, Cody R. Goodwin, Lucas H. Hofmeister, Deyu Li, Dmitry A. Markov, Jody C. May, Lisa J. McCawley, BethAnn McLaughlin, John A. McLean, Kevin D. Niswender, Virginia Pensabene, Kevin T. Seale, Stacy D. Sherrod, Hak-Joon Sung, David L. Tabb, Donna J. Webb, and John P. Wikswo, Neurovascular unit on a chip: implications for translational applications, Stem Cell Research and Therapy 2013. 4(Suppl 1):S18





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    74. Mingjian Shi, Devi Majumdar, Yandong Gao, Bryson M. Brewer, Cody R. Goodwin, John A. McLean, Deyu Li, and Donna J. Webb, Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts , Lab on a Chip 2013. 13: 3008-3021.






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    73. Kelly M. Hines, Samir Ashfaq, Jeffrey M. Davidson, Susan R. Opalenik, John P. Wikswo, and John A. McLean, Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry, Analytical Chemistry 2013. 85(7) 3651-3659.






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    71. John P. Wikswo,Fellow, IEEE , Frank E. Block III, David E. Cliffel, Cody R. Goodwin, Christina C. Marasco, Dmitry A. Markov, David L. McLean, John A. McLean, Jennifer R. McKenzie, Ronald S. Reiserer, Philip C. Samson, David K. Schaffer, Kevin T. Seale, and Stacy D. Sherrod, Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems, IEEE Transactions on Biomedical Engineering 2013. 60(3) 682-690.



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  • Book Chapter
    69. Larissa S. Fenn and John A. McLean, Structural Separations by Ion Mobility-MS for Glycomics and Glycoproteomics in Mass Spectrometry of Glycoproteins: Methods and Protocols. Jennifer J. Kohler and Steven M. Patrie Eds. Humana Press. 2013.






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2012


  • 68. Jay G. Forsythe, Joshua A. Broussard, Jenifer L. Lawrie, Michal Kliman, Yang Jiao, Sharon M. Weiss, Donna J. Webb, and John A. McLean, Semitransparent Nanostructured Films for Imaging Mass Spectrometry and Optical Microscopy, Analytical Chemistry 2012 84(24), 10665-10670.



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  • Book Chapter
    67. Kelly M. Hines, Jeffrey R. Enders, and John A. McLean, Multidimensional Separations by Ion Mobility-Mass Spectrometry in Encyclopedia of Analytical Chemistry. Robert Myers and David Muddiman Eds. John Wiley & Sons, Ltd. December 2012.





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  • 66. Committee on Assessment of Agent Monitoring Strategies for the Blue Grass and Pueblo Chemical Agent Destruction Pilot Plants, Board on Army Science and Technology, Division on Engineering and Physical Sciences, National Research Council (NRC Committee: C.E. Kolb (Chair), J.L. Beauchamp, R.A. Beaudet, J.B. Berkowitz, H. Chem, A.T. Cooper, F.M. Fernandez, R.D. Gibbons, J.A. McLean, M.D. Morris, D.W. Murphy, C.S. Reese, L.R. Rhomberg, and A.A. Viggiano. "Executive Summary." Assessment of Agent Monitoring Strategies for the Blue Grass and Pueblo Chemical Agent Destruction Pilot Plants. Washington, DC: The National Academies Press, 2012. The National Academies Press 2012.


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  • 65. Jeffrey R. Enders, Christina C. Marasco, John P. Wikswo, and John A. McLean, A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry, Analytical Chemistry 2012, 84(20), 8467-8474.





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  • 64. Kellen M. Harkness, Yun Tang, Amala Dass, Jun Pan, Nuwan Kothalawala, Vijay J. Reddy, David E. Cliffel, Borries Demeler, Francesco Stellacci, Osman M. Bakr, and John A. McLean, Ag44(SR)304-: a silver-thiolate superatom complex, Nanoscale 2012, 4, 4269-4274.





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  • 63. Kellen M. Harkness, Brian N. Turner, Amanda C. Agrawal, Yibin Zhang, John A. McLean, and David E. Cliffel, Biomimetic monolayer-protected gold nanoparticles for immunorecognition, Nanoscale 2012, 4, 3843-3851.







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  • 62. Andreas Matusch, Larissa S. Fenn, Candan Depboylu, Martin Klietz, Sven Strohmer, John A. McLean, and Johanna Sabine Becker, Combined elemental and biomolecular mass spectrometry imaging (MSI) for probing the inventory of tissue at a micrometer scale, Analytical_Chemistry 2012, 84(7) 3170-3178.




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  • 61. Cody R. Goodwin, Larissa S. Fenn, Dagmara K. Derewacz, Brian O. Bachmann, and John A. McLean Structural Mass Spectrometry: Rapid Methods for Separation and Analysis of Peptide Natural Products, Journal_of_Natural_Products 2012, 75(1) 48-53
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2011


  • 60. Jeffrey R. Enders, Cody R. Goodwin, Christina C. Marasco, Kevin T. Seale, John P. Wikswo, and John A. McLean, Advanced structural mass spectrometry for systems biology: Pulling the needles from haystacks, Current Trends in Mass Spectrometry July 2011.




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  • 58. M. Kliman, J. C. May, and J. A. McLean, Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry, Biochimica et Biophysica Acta 2011,1811:(11) 935-945. Invited submission for special issue entitled Lipidomics and Imaging Mass Spectrometry.




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  • Book Chapter
    57. Jeffrey R. Enders, Michal Kliman, Sevugarajan Sundarapandian, John A. McLean. Peptide and Protein Analysis using Ion Mobility-Mass Spectrometry in Protein and Peptide Mass Spectrometry in Drug Discovery. Michael L. Gross, Ben Pramanik, Guodong Chen Eds. John Wiley & Sons, Inc. 2011, pgs. 139-174.





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  • Book Chapter
    56. J. C. May and J. A. McLean, The conformational landscape of biomolecules i n ion mobility-mass spectrometry. Invited chapter for inclusion in Ion Mobility Spectrometry: Theory and Applications, Charles L. Wilkins and Sarah Trimpin Eds. CRC Press 2011, pgs.327-343.






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2010


  • 53. Harkness, Kellen; Hixson, Brian; Fenn, Larissa; Turner, Brian; Rape, Amanda; Simpson, Carrie; Huffman, Brian; Okoli, Tracy; McLean, John; Cliffel, David, A Structural Mass Spectrometry Strategy for the Relative Quantitation of Ligands on Mixed Monolayer-Protected Gold Nanoparticles, Analytical Chemistry 2010, 82 (22):9268-9274.




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  • Book Chapter
    52. John A. McLean, J. Albert Schultz, and Amina S. Woods. Ion Mobility-Mass Spectrometry for Biological and Structural Mass Spectrometry. Included in "Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicabilities, and Biological Applications", Richard B. Cole, Ed. John Wiley & Sons 2010, pgs. 411-439.







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  • 51. Jeffrey R. Enders, Christina C. Marasco, Ayeeshik Kole, Bao Nguyen, Sevugarajan Sundarapandian, Kevin T. Seale, John P. Wikswo, and John A. McLean, Towards monitoring real-time cellular response using an integrated microfluidics-MALDI/nESI-ion mobility-mass spectrometry platform, IET Systems Biology 2010, 4 (6):416-427.





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  • 49. S. Sevugarajan, J. C. May, J. A. McLean, A dual source ion mobility-mass spectrometer for direct comparison of ESI and MALDI collision cross section measurements, Analytical Chemistry 2010, 82(8):3247-3254.






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  • 48. K. Harkness, L.S. Fenn, D.E. Cliffel, and J.A. McLean, Surface Fragmentation of Complexes from Thiolate Protected Gold Nanoparticles by Ion Mobility-Mass Spectrometry, Analytical Chemistry 2010, 82(7):3061-3066.






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  • Cover:

    47. M. Kliman, N. Vijayakrishnan, L. Wang, J. T. Tapp, K. Broadie, J. A. McLean, Structural mass spectrometry analysis of lipid changes in a drosophila epilepsy model brain, Molecular BioSystems 2010, 6(6):958-966.
















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  • 46. W. B. Ridenour, M. Kliman, J. A. McLean, R. M. Caprioli, Structural characterization of phospholipids and peptides directly from tissue sections by MALDI traveling-wave ion mobility-mass spectrometry, Analytical Chemistry 2010, 82(5):1881-1889.






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  • 45. J. R. McLean, J. A. McLean, Z. Wu, C. S. Becker, L. Perez, C. N. Pace, J. M. Scholtz, D. H. Russell, Factors that influence helical preferences for singly-charged gas-phase peptide ions: the side effects of multiple potential charge-carrying sites, Journal of Physical Chemistry B. 2010, 114(2):809-816.






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  • Book Chapter
    44. John A. McLean, Larissa S. Fenn, and Jeffrey R. Enders. Structurally Selective Imaging Mass Spectrometry by Imaging Ion Mobility-Mass Spectrometry. Invited chapter for inclusion in "Mass Spectrometric Imaging: History, Fundamentals and Protocols", Methods in Molecular Biology Series, Jonathan Sweedler and Stanislav Rubakhin, Eds. Humana Press 2010, pgs.363-383 .




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  • 42. K. Harkness, D.E. Cliffel, and J.A. McLean, Characterization of Thiolate-Protected Gold Nanoparticles by Mass Spectrometry, Analyst 2010, 135:868-874.









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2009


  • 41. Enders J. R., McLean J. A. Chiral and Structural Analysis of Biomolecules Using Mass Spectrometry and Ion Mobility-Mass Spectrometry. Chirality 2009, 21:S253-S264.








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2008









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  • Patent
    McLean, J. A., Russell, D. H., Egan, T. F., Ugarov, M. V. and Schultz, J. A. Multiplex Data Acquisition Modes for Ion Mobility-Mass Spectrometry. U. S. patent No. 2008: 7,388,197.







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       2007

  • 31. McLean, J. A., Russell, D. H. Advanced Optics for Rapidly Patterned Laser Profiles in Analytical Mass Spectrometry. U. S. patent No. 2007: 7,282,706.

  • 30. McLean J. A. , Ridenour W. B. , Caprioli R. M. Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. International Journal of Mass Spectrometry. 2007, 42 (8): 1099-1105.

  • 29. Sherrod, S. D., Castellana, E. T., McLean, J. A. and Russell, D. H. Spatially dynamic laser patterning using advanced optics for imaging matrix assisted laser desorption/ionization (MALDI) mass spectrometry. Journal of Mass Spectrometry. 2007, 262: 256-262.


Prior to Vanderbilt University





       2006

  • McLean, J. A., Russell, D. H. and Schultz, J. A. Gas-Phase Purification of Biomolecules by Ion Mobility for Patterning Microarrays and Protein Crystal Growth. U.S. patent No. 2006: 7,081,617.

       2005

  • 28. McLean, J. A., Ruotolo, B. T., Gillig, K. J., Russell, D. H. Ion Mobility-Mass Spectrometry: A New Paradigm for Proteomics. International Journal of Mass Spectrometry. 2005, 240: 301-315.

  • 27. McLean, J. A., Schultz, J. A., Ugarov, M. V., Egan, T. F., Russell, D. H. Ultrafast Two-Dimensional Ion Separations Based on Ion Mobility-Time-of-Flight Mass Spectrometry: From Biotechnology to Nanotechnology. Braz. J. Vac. Appl. 2005, 24: 3-9.

  • 26. McLean, J. A., Stumpo, K. A., Russell, D. H. Size-Selected (2-10 nm) Gold Nanoparticles for Matrix Assisted Laser Desorption Ionization of Peptides. Journal of the American Chemical Society. 2005, 127: 5304-5305.

  • 25. McLean, J. A., Russell, D. H. Multiplex Data Acquisition Based on Analyte Dispersion in Two Dimensions: More Signal More of the Time. International Journal Ion Mobility Spectrometry. 2005, 8: 66-71.

  • 24. McLean, J. A., Russell, D. H. New Vistas for New Vistas for Mass Spectrometry Based Proteomics and Biotechnology: Rapid Two-Dimensional Separations Using Gas-Phase Electrophoresis/Ion Mobility-Mass Spectrometry. American Biotechnology Laboratory. 2005, 23: 18-21.

  • 23. B. T. Ruotolo, J. A. McLean, K. J. Gillig, and D. H. Russell. The influence and utility of varying field strength for the separation of tryptic peptides by ion mobility-mass spectrometry. Journal of the American Society for Mass Spectrometry. 2005, 16: 158-165.

       2004


  • 22. B. T. Ruotolo, J. A. McLean, K. J. Gillig, and D. H. Russell. Peak capacity of ion mobility mass spectrometry: The utility of varying drift gas polarizability for the separation of tryptic peptides. Journal of Mass Spectrometry. 2004, 39: 361-367.

  • 21. C. S. Westphal, J. A. McLean, S. J. Hakspiel, W. E. Jackson, D. E. McClain, and A. Montaser. Determination of Depleted Uranium in Urine via Isotope Ratio Measurements Using Large-Bore Direct Injection High Efficiency Nebulizer-Inductively Coupled Plasma Mass Spectrometry . Appl. Spectrosc.. 2004, 58: 1044-1050.

       2003


  • 20. J. A. McLean, and D. H. Russell. Sub-Femtomole Peptide Detection in Ion Mobility-Time-of-Flight Mass Spectrometry Measurements . J. Proteome Res.. 2003, 2: 427-430.

  • 19. J. A. McLean, W. K. Russell, and D. H. Russell. A High Repetition Rate (1 kHz) Micro-Crystal Laser for High Throughput Atmospheric Pressure MALDI-Quadrupole-Time-of-Flight Mass Spectrometry . Anal. Chem.. 2003, 75: 648-654.

       2002


  • 18. J. M. Koomen, B. T. Ruotolo, K. J. Gillig, J. A. McLean, D. H. Russell, M. Kang, K. R. Dunbar, K. Fuhrer, M. Gonin, and J. A. Schultz. Oligonucleotide Analysis with MALDI-Ion Mobility-TOFMS. Anal. Bioanal. Chem.. 2002, 373: 612-617.

  • 17. S. F. Boulyga, J. L. Matusevich, V. P. Mironov, V. P. Kudrjashov, L. Halicz, I. Segal, J. A. McLean, A. Montaser, and J. S. Becker. Determination of 236U/238U Isotope Ratio in Contaminated Environmental Samples Using Different ICP-MS Instruments. J. Anal. At. Spectrom.. 2002, 17: 958-964.

  • 16. S-A. E. O’Brien, J. A. McLean, B. W. Acon, B. J. Eshelman, W. F. Bauer, and A. Montaser. Determination of Memory-Prone Elements Using Direct Injection High Efficiency Nebulizer Inductively Coupled Plasma Mass Spectrometry. Appl. Spectrosc.. 2002, 56: 1006-1012.

  • 15. C. S. Westphal, J. A. McLean, B. W. Acon, L. A. Allen, and A. Montaser. Axial Inductively Coupled Plasma Time-of-Flight Mass Spectrometry Using Direct Liquid Sample Introduction. J. Anal. At. Spectrom.. 2002, 17: 669-675.

       2001


  • 14. B. W. Acon, J. A. McLean, and A. Montaser. A Direct Injection High Efficiency Nebulizer Interface for Microbore High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry. J. Anal. At. Spectrom.. 2001, 16: 852-857.

  • 13. J. A. McLean, J. S. Becker, S. Boulyga, H.-J. Dietze, and A. Montaser. Ultratrace and Isotopic Analysis of Long-Lived Radionuclides by Double-Focusing Sector Field Inductively Coupled Plasma Mass Spectrometry Using Direct Liquid Sample Introduction. Int. J. Mass Spectrom.. 2001, 208: 193-204.

  • 12. M. G. Minnich, J. A. McLean, and A. Montaser. Rapid Elucidation of Spatial Aerosol Characteristics of a Direct Injection High Efficiency Nebulizer via Optical Patternation. Spectrochim. Acta.. 2001, 56B: 1113-1126.

       2000


  • 11. J. A. McLean, M. G. Minnich, A. Montaser, J. Su, and W. Lai. Optical Patternation: A Technique for Three Dimensional Aerosol Diagnostics. Anal. Chem.. 2000, 72: 4796-4804.

  • 10. B. W. Acon, J. A. McLean, and A. Montaser. A Large Bore-Direct Injection High Efficiency Nebulizer for Inductively Coupled Plasma Spectrometry. Anal. Chem.. 2000, 72: 1885-1893.

  • 9. J. A. McLean, B. W. Acon, A. Montaser, J. Singh, D. E. Pritchard, and S. R. Patierno. Determination of Chromium in Human Lung Fibroblast Cells Using a Large-Bore Direct Injection High Efficiency Nebulizer with Inductively Coupled Plasma Mass Spectrometry. Appl. Spectrosc.. 2000, 54: 659-663.

       1999


  • 8. J. Singh, D. E. Pritchard, D. L. Carlisle, J. A. McLean, A. Montaser, J. M. Orenstein, and S. R. Patierno. Internalization of Carcinogenic Lead Chromate Particles by Cultured Normal Human Lung Epithelial Cells: Formation of Intracellular Lead-Inclusion Bodies and Induction of Apoptosis. Toxicol. Appl. Pharmacol.. 1999, 161: 240-248.

  • 7. J. A. McLean, R. A. Huff, and A. Montaser. Fundamental Aerosol Properties in Helium Using a Direct Injection Nebulizer. Appl. Spectrosc.. 1999, 53: 1331-1340.

  • 6. J. S. Becker, H.-J. Dietze, J. A. McLean, and A. Montaser. Ultratrace and Isotope Analysis of Long-Lived Radionuclides by Inductively Coupled Plasma Quadrupole Mass Spectrometry Using a Direct Injection High Efficiency Nebulizer. Anal. Chem.. 1999, 71: 3077-3084.

       1998


  • 5. Book Chapter A. Montaser, J.A. McLean, H. Liu, and J-M. Mermet. “Introduction to ICP Spectrometries for Elemental Analysis”, in Inductively Coupled Plasma Mass Spectrometry. A. Montaser Ed. Wiley-VCH, New York. 1998.

  • 4. Book Chapter A. Montaser, M. G. Minnich, J. A. McLean, H. Liu, J. A. Caruso and C. W. McLeod. “Sample Introduction in ICPMS”, in Inductively Coupled Plasma Mass Spectrometry. A. Montaser Ed. Wiley-VCH, New York. 1998.

  • 3. J. Singh, J. A. McLean, D. E. Pritchard, A. Montaser, and S. R. Patierno. Sensitive Quantitation of Chromium-DNA Adducts by Inductively Coupled Plasma Mass Spectrometry with a Direct Injection High Efficiency Nebulizer . Toxicol. Sci.. 1998, 46: 260-265.

  • 2. J. A. McLean, M. G. Minnich, L. A. Iacone, H. Liu, and A. Montaser. Nebulizer Diagnostics: Fundamental Parameters, Challenges, and Techniques on the Horizon. J. Anal. At. Spectrom.. 1998, 13: 829-842.

  • 1. J. A. McLean, H. Zhang, and A. Montaser. A Direct Injection High-Efficiency Nebulizer for Inductively Coupled Plasma Mass Spectrometry. Anal. Chem.. 1998, 70: 1012-1020.