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    Micro-Fluidics and Nanosensing
  • "Free-solution Interaction Assay of Carbonic Anhydrase to its Inhibitors Using back-scattering Interferometry." E. Morcos, A. Kussrow, C. S. Enders, D.J. Bornhop. Electrophoresis, In Press (2010).

  • “The potential of Backscattering Interferometry as an in vitro Clinical Diagnostic Tool for the Serological Siagnosis of Infectious Disease.” A. Kussrow, C. S.  Enders, A. R. Castro, D.L. Cox, R. C. Ballard, D.J. Bornhop, Analyst, 135, 1535-1537 (2010).

  • “Characterizing Molecular Interactions: Label-free, Back-Scattering Interferometry.”  A. Kussrow, D. J. Bornhop, N. Harris, S. Dotson, S. Weinberger, W. Rich, Screening Trends in Drug Discovery, 10, 14-16 (2009).

  • “Backscattering Interferometry for Low Sample Consumption Molecular Interaction Screening.” A. Kussrow, C. S. Enders, E. F. Morcos, D. J. Bornhop, Journal of the Association for Laboratory Automation, 14, 341-347 (2009).

  • “Measurement of Monovalent and Polyvalent Carbohydrate-Lectin Binding by Back-Scattering Interferometry.” A. Kussrow, E. Kaltgrad, M. L. Wolfenden, M. J. Cloninger, M. G. Finn. D. J. Bornhop, Analytical Chemistry, 81, 4889-4897 (2009).

  • "Free-solution Label-free studies of α-Crystallin – Charparone Protein Interactions by Back-scattering Interferometry.” J. C. Latham, R. A. Stein, D. J. Bornhop, H. Mchaourab, Analytical Chemistry, 81, 1865-1871 (2009).

  • “Free-Solution, Label-Free Molecular Interactions Studied by Back-scattering Interferometry.” D. J. Bornhop, J. C. Latham, A. Kussrow, D. A. Markov, R. D. Jones, H. S. Sørensen, Science, 317, 1732-1736 (2007).

  • “Highly Sensitive Biosensing based on Interference from Light Scattering in Capillary Tubes.” H. S. Sørensen, N. B. Larsen, J. C. Latham, D. J. Bornhop, P. E. Andersen, Applied Physics Letters, 89, 151108 (2006).

  • “Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter Volume Refractive Index Detection with Gradient Compensation.” Z. Wang, D. J. Bornhop, Analytical Chemistry, 77, 7872-7877 (2005).

  • “Label-Free Molecular Interaction Determinations with Nanoscale Interferometry.” D. Markov, K. Swinney, D. J. Bornhop, Journal of the American Chemical Society, 126, 16659-16664 (2004).

  • “Non-Invasive Fluid Flow Measurements in Microfluidic Channels with Backscatter Interferometry.” D. A. Markov, S. Dotson, S. Wood, D. J. Bornhop, Electrophoresis, 25, 3805-3809 (2004).

  • “Absolute Refractive Index Determination by Micro-Interfermometric Backscatter Detection.” H. S. Sørensen, H. Pranov, N. B. Larsen, D. J. Bornhop, P. E. Andersen, Analytical Chemistry, 75, 1946-1953 (2003).

  • “Attomole Sensitivity for Proteins and Polypeptides with On-chip CE and Universal Detection by Interferometric Backscatter.” Z. Wang, K. Swinney, D. J. Bornhop, Electrophoresis, 24, 865-873 (2003).

  • “Breaking the 10-7 for RI Measurements in Nanoliter Volumes.” D. Markov, D. Begari, D. J. Bornhop, Analytical Chemistry, 74, 5438-5441 (2002).

  • “A Fourier Analysis Approach for Capillary Polarimetry.” D. Markov, K. Norville, D. Lu, K. Swinney, D. J. Bornhop, Electrophoresis, 23, 809-812 (2002).

  • “Nanoliter Volume Polarimetry.” K. Swinney J. Nodorft, D.J. Bornhop, Applied Spectroscopy, 56, 134-138 (2002).

  • “Quantification and Evaluation of Joule Heating in On-Chip CE.” K. Swinney, D. J. Bornhop, Electrophoresis, 23, 621-625 (2002).

  • “Nanoliter-scale Non-invasive Flow-Rate Quantification using Micro-Interferometric Backscatter and Phase Detection.” D. Markov, D. J. Bornhop, Fresenius’ Journal Analytical Chemistry, 371, 234-237 (2001).

  • “Non-Invasive Picoliter Volume Thermometry Based on Backscatter Interferometry.” K. Swinney, D. J. Bornhop, Electrophoresis, 22, 2032-2036 (2001).

  • “Capillary-Scale Polarimetry for Flowing Streams.” K. Swinney, J. Nodorft, D. J. Bornhop, Analyst, 126, 673-675 (2001).

  • “A Chip-Scale Universal Detector for Electrophoresis Based on Backscattering Interferometry.” K. Swinney, D. J. Bornhop, Analyst, 125, 1713-1717 (2000).

  • “D-β-Hydroxybutrate Reaction Kinetics Studied in Nanoliter Volumes using a Capillary Polarimeter.” K. Swinney, D. J. Bornhop, Applied Spectroscopy, 54, 1458-1469 (2000).

  • “Chip-Scale Universal Detection using Backscattering Interferometry.” K. Swinney, D. Markov, D. J. Bornhop, Analytical Chemistry, 72, 2690-2695 (2000).

  • “Detection in Capillary Electrophoresis: A Review.” D. J. Bornhop, K. Swinney, Electrophoresis, 21, 1239-1250 (2000).

  • “Ultra-Small Volume Refractive Index Detection using Micro-Interferometry.” K. Swinney, D. Markov, D. J. Bornhop, Review of Scientific Instruments, 71, 2684-2693 (2000).

  • “A Review of CE Detection Methodologies.” K. Swinney, D.J. Bornhop, CRC Critical Reviews in Analytical Chemistry, 30, 1-30 (2000).

    Multi-Modal Molecular Imaging Agent
  • “Molecular Imaging of the Translocator Protein (TSPO) in a Pre-Clinical Model of Breast Cancer.” S. Wyatt, H. C. Manning, M. Bai, S. N. Bailey, P. Gallant, G. Ma, L. McIntosh, D. J. Bornhop, Molecular Imaging and Biology, 12, 349-358 (2010).

  • “Binding of NIR-conPK and NIR-6T to Astrocytomas and Microglial Cells: Evidence for a Protein related to TPSO.” M. Sexton, G. Woodruff, E. Cudaback, F. R. Kreitxer, C. Xu, Y. H. Lin, T. Möller, M. Bai, H. C. Manning, D. J. Bornhop, N. Stella, PLoS One, 4, e8271 (2009).

  • “TSPO Targeted Dendrimer Imaging Agent: Synthesis, Characterization and Cellular Internalization.” L. E. Samuelson, M. J. Dukes, C. R. Hunt, J. D. Casey, D. J. Bornhop, Bioconjugate Chemistry, 20, 2082-2089 (2009).

  • "Molecular imaging of therapeutic response to EGF receptor blockade in colorectal cancer." H. C. Manning, N. B. Merchant, A. C. Foutch, J. M. Virostko, S. K. Wyatt, C. Shah, E. T. McKinley, J. Xie, N. J. Mutic, M. K. Washington, B. LaFleur, M. N. Tantawy, T. E. Peterson, M. S. Ansari, R. M. Baldwin, M. L. Rothenberg, D. J. Bornhop, J. C. Gore, R. J. Coffey, Clinical Cancer Research, 15, 7413-7422 (2008).

  • “MBC94, A Conjugable Ligand for Cannabinoid CB2 Receptor Imaging.” M. Bai, M. Sexton, N. Stella, D. J. Bornhop, Bioconjugate Chemistry, 19, 988-992 (2008).

  • “Role of the Antenna in Tissue Selective Probes Built of Lanthanide-Organic Chelates.” B. Hess, A. Kedziorski, L. Smentek, D. J. Bornhop, The Journal of Physical Chemistry, 112, 2397-2407 (2008).

  • “A Novel Functions Translocator Protein Ligand for Cancer Imaging.” M. Bai, M. B. Rone, V. Papadopoulos, D.J. Bornhop, Bioconjugate Chemistry, 18, 2018-2023 (2007).

  • “Novel Conjugable Translocator Protein Ligand Labeled with a Fluorescence Dye for in Vitro Imaging.” M. Bai, S. K. Wyatt, Z. Han, V. Papadopoulos, D. J. Bornhop, Bioconjugate Chemistry, 18, 1118-1122 (2007).

  • “Targeted Imaging of Colonic Tumors in Smad3-/-Mice Discriminates Cancer and Inflammation.” N. G. Deane, H. C. Manning, A. C. Foutch, M. K. Washington, B. A, Aronow, D. J. Bornhop, R. J. Coffey, Molecular Cancer Research, 5, 341-349, (2007).

  • “A Peripheral Benzodiazepine Receptor Targeted Agent for In Vitro Imaging and Screening.” H. C. Manning, S. M. Smith, S. Haviland, M. Sexton, M. Bai, K. Cederquist, D. J. Bornhop, Bioconjugate Chemistry, 17, 735-740 (2006).

  • “Density Function Theory Structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for Ions Across the Lanthanide Series.” L. Smentek, B. A. Hess, Jr., J. P. Cross, H. C. Manning, D. J. Bornhop, Journal of Chemical Physics, 123, 244302 (2005).

  • “Expeditious Synthesis of P-protected Macrocycles In-route to Lanthanide Chelate Metal Complexes.” H. C. Manning, B. Anderson, L. Samuelson, S. Havaland, D. J. Bornhop, Teterahedron Letters, 46, 4707-4710 (2005).

  • “Targeted Molecular Imaging Agent for Cellular-Scale Bi-modal Imaging.” H. C. Manning, J. M. M. Griffin, T. S. Goebel, M. A. Wegiel, R. C. Thompson, R. R. Price, D. J. Bornhop, Bioconjugate Chemistry, 15, 1488-1495 (2004).

  • “Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent.” X. Wang, G. Ku, M. A. Wegiel, D. J. Bornhop, G. Stoica, L. V. Wang, Optics Letters, 29, 730-732 (2004).

  • “Lanthanide Chelate Contrast Agents for the Detection of Malignant Lesions in the Syrian Hamster Cheek Pouch.” T. S. Goebel, J. M. M. Griffin, B. Bell, M. Motamedi, D. J. Bornhop, Applied Spectroscopy, 57, 1216-1222 (2003).

  • “Rapid Removal of Benzyloxycarbonyl Groups from 1,4,7,10-Tetraazacyclodododecance Derivatives by Catalytic Transfer Hydrogenation.” H. C. Manning, A. M. Skwierawska, J. N. Marx, D. J. Bornhop, Synthetic Communications, 33, 457-461 (2003).

  • “Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Ligand Analogue.” H. C. Manning, T. Goebel, J. N. Marx, D. J. Bornhop, Organic Letters, 4, 1075-1078 (2002).

  • “Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates.” J. M. M. Griffin, A. M. Skwierawska, H. C. Manning, J. N. Marx, D. J. Bornhop, Tetrahedron Letters, 42, 3823-3825 (2001).

  • “Advances in Contrast Agents, Reporters and Detection.” D. J. Bornhop, C. H. Contag, K. Licha, C. J. Murphy, Journal of Biomedical Optics, 6, 106-110 (2001).

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