Dr. Bornhop
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Contrast Enhanced Spectroscopic Detection of Oral Cancer  
On-Chip Interferometry  
Lanthanide Chelate Multi-modal Molecular Imaging Agents  
Darryl Bornhop Published in Science, September 2007  
C&E News Citation on Microscale Polarimetry (PDF)  
 

 

 

 

 

 
 
 
Department of Chemistry
Vanderbilt University
VU Station B Box 351822
Nashville, TN 37235-1822
(615) 322-4226
darryl.bornhop@vanderbilt.edu

EDUCATION:

  • 1987 Ph.D., Analytical Chemistry, University of Wyoming; (Mentor: Norman J. Dovichi)

  • 1982 M.A., Environmental Science, University of Missouri, Columbia

  • 1980 B.S., Chemistry, University of Missouri, Columbia

PROFESSIONAL EXPERIENCE:

  • 2003-Present Professor, Department of Chemistry, Vanderbilt University

  • 2002-2003 Professor, Department of Chemistry and Biochemistry, Texas Tech

  • 1994-2003 Research Faculty, Southwest Cancer Center, University Medical Center, Texas Tech

  • 1998-2002 Associate Professor, Department of Chemistry and Biochemistry, Texas Tech

  • 1994-1998 Assistant Professor, Department of Chemistry and Biochemistry, Texas Tech

  • 1989-1994 Adjunct Assistant Professor, Department of Biochemistry, University of Nevada

  • 1993-1994 Vice President Research and Development, MediVisions, Inc., Seattle, WA

  • 1991-1993 Senior R&D Engineer, Citation Medical, Reno, NV

  • 1989-1991 Product Development Group Leader, Linear Instruments Division of Spectra Physics, Reno, NV

  • 1987-1989 Research and Development Group Leader, Lee Scientific Inc. (Dionex), Salt Lake City, UT

RESEARCH INTERESTS:

Multi-disciplinary bioanalytical and biomedical research and the general application of micro-imaging for nanoscale chemical/biochemical analysis.

RESEARCH CURRENTLY UNDERWAY:

  • The synthesis, characterization and application of exogenous markers (particularly multi-modal signaling agents) for early disease detection, diagnosis and in-vitro assays.

  • The quantification of solute transport in pathological tissue and the elucidation of mechanisms for M-cells involvement in chemical carcinogenesis.

  • The application of lasers to nanoscale chemical and biochemical analysis, particularly for nano-scale investigations such as label-free protein sequencing.

  • The use of micro-fluidics for on-chip patterning, high throughput screening, rapid biochemical assays, proteomics and point of care analysis.

HONORS:

  • 2001 - Present Scientific Advisory Board; CelTor Biosystems

  • 2001 NSF Biomedical Engineering Review Panel Member

  • 2001 - Present Scientific Committee LabAutomation

  • 2000 - Present Scientific Committee SmallTalk Conference

  • 2000 NSF Biomedical Engineering Review Panel Member

  • 1999 (Summer) Visiting Professor, Freie University, Berlin

  • 1999-2001 Scientific Advisory Board; Torsana Biodiagnositics A/S

  • 1998-present Member; NIH - NCRR Study Panel

  • 1996-2000 Whitaker Foundation Biomedical Engineering Award

  • 1989 Technical Leadership Award, Lee Scientific

  • 1983 Research Creativity Grant-Award, Montana State University

PROFESSIONAL MEMBERSHIPS:

  • American Chemical Society

  • American Association for the Advancement of Science

  • Biomedical Optics Society

  • Optical Society of America

  • International Society for Optical Engineering (SPIE)

  • Association for Laboratory Automation

  • Institute for Biotechnology, Texas Tech University

  • Basic Research Group, Southwest Cancer Center UMC

SELECTED PUBLICATIONS:

  • D.J. Bornhop and J. Hankins, "Polarimetry in Capillary Dimensions", Analytical Chemistry, 68:1677-1684, (1996). Cover article for the May 15 Issue.

  • M.P. Houlne, D.S. Hubbard, G.E. Kiefer and D.J. Bornhop, "Imaging and Quantitation of Tissue Selective Lanthanide Chelates Using an Endoscopic Fluorometer", J. Biomedical Optics, 3:145-153, (1998).

  • D.J. Bornhop, D.S. Hubbard, M.P. Houlne, C. Adair, G.E. Kiefer, B.C. Pence and D.L. Morgan, "Fluorescent Tissue Site-Selective Lanthanide Chelate, Tb-PTCMB for Enhanced Imaging of Cancer", Analytical Chemistry, 71:2607-2615, (1999).

  • K. Swinney, D. Markov and D.J. Bornhop, "Chip-Scale Universal Detection using Backscattering Interferometry", Analytical Chemistry, 72: 2690-2695, (2000). This was an Accelerated Article.

  • J.M.M. Griffin, A.M. Skwierawska, H.C. Manning, J.N. Marx and D.J. Bornhop, "Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates", Tetrahedron Letters, 42, 3823-3825, (2001).

  • K. Swinney and D.J. Bornhop, "Quantification and Evaluation of Joule Heating in On-Chip CE", Electrophoresis, Vol. 23 (4): 621-625 (2002).

  • H.C. Manning, T. Goebel, J.N. Marx and D.J. Bornhop, "Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Ligand Analogue", Organic Letters, 4(7), 1075-1078, (2002).

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