Professor of Chemistry
Ph.D., University of California, Berkeley, 1969
joel.tellinghuisen@vanderbilt.edu
Teaching Web Page

Chemical Physics, Physical Chemistry, Chemometrics
My research interests span a range of topics, from high-resolution optical spectroscopy of diatomic molecules to solution calorimetry. An underpinning theme of most of this work is the development of computational methods for interpreting and analyzing data, with attention to both research and pedagogical aspects of the primary tool for data analysis by physical scientists - the method of least squares.


My recent spectroscopic projects have included studies of direct fitting methods for both high- and low-resolution absorption and emission spectra, precise determination of absorption oscillator strengths, and the interplay between absorption spectrometry and equilibrium. The calorimetry work has focused on a better understanding of the method of isothermal titration calorimetry (ITC), which has exploded in popularity in recent years as the method of choice for the study of binding and complexation.


These studies have practical applications in a number of areas. For example, ITC is widely used in the search for new pharmaceuticals. However, my work in these areas is strongly fundamental, hence truly "academic." As such, it is particularly appropriate for those interested in preparing for a career in education.

Selected Publications

Tellinghuisen J. Least Squares in Calibration: Weights, Nonlinearity, and other Nuisances. Methods in Enzymology: Computer Methods. 2009, 454: 259-285.

Tellinghuisen J, Bolster CH. Weighting Formulas for the Least-Squares Analysis of Binding Phenomena Data  . Journal of Physical Chemistry B. 2009, 113 (17): 6151-6157.

Tellinghuisen J. Least squares with non-normal data: estimating experimental variance functions. Analyst. 2008, 133 (2): 161-166.

Tellinghuisen J, Sulikowski MM. Does the answer order matter on multiple-choice exams?. Journal of Chemical Education. 2008, 85 (4): 572-575.

Tellinghuisen J. Equilibrium constants from spectrophotometric data: Dimer formation in gaseous Br-2. Journal of Physical Chemistry A. 2008, 112 (26): 5902-5907.

Zeng QC, Zhang E, Dong H, Tellinghuisen J. Weighted least squares in calibration: Estimating data variance functions in high-performance liquid chromatography. Journal of Chromatography A. 2008, 1206 (2): 147-152.

Tellinghuisen J. Weighted least squares in calibration: The problem with using "quality coefficients" to select weighting formulas. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life. 2008, 872 (1-2): 162-166.

Zeng QC, Zhang E, Tellinghuisen J. Univariate calibration by reversed regression of heteroscedastic data: a case study. Analyst. 2008, 133 (12): 1649-1655.

Tellinghuisen J. Isothermal titration calorimetry at very low c. Analytical Biochemistry. 2008, 373 (2): 395-397.

Xu J, Reiserer R, Tellinghuisen J, Wikswo JP, Baudenbacher FJ. A Microfabricated Nanocalorimeter: Design, Characterization, and Chemical Calibration. Analytical Chemistry. 2008, 80 (8): 2728-2733.

Tellinghuisen J. Optimizing experimental parameters in isothermal titration calorimetry: Variable volume procedures. Journal of Physical Chemistry. 2007, B 111 (39): 11531-11537.

Tellinghuisen J. Weighted least-squares in calibration: what difference does it make?. The Analyst. 2007, 132 (6): 536-43.

Tellinghuisen J. Laser-induced fluorescence in gaseous I-2 excited with a green laser pointer. Journal of Chemical Education. 2007, 84 (2): 336-341.

Tellinghuisen J. Calibration in isothermal titration calorimetry: Heat and cell volume from heat of dilution of NaCl(aq). Analytical Biochemistry. 2007, 360 (1): 47-55.

Tellinghuisen J. Achieving Chemical Equilibrium: The Role of Imposed Conditions in the Ammonia Formation Reacation. Journal of Chemical Education. 2006, 83: 1090-1093.

Tellinghuisen J. Need a single-mode red laser, cheap? Check your pockets!. Journal of Chemical Physics. 2006, 124: 236-101.

Tellinghuisen J. Van't Hoff analysis of K-(T): How good...or bad. Biophysical Chemistry. 2006, 120 (2): 114-120.

Quisenberry KT, Tellinghuisen J. Textbook deficiencies: Ambiguities in chemical kinetics rates and rate constants. Journal of Chemical Education. 2006, 83 (3): 510-512.

Tellinghuisen J. First-order or second-order kinetics? A Monte Carlo answer. Journal of Chemical Education. 2005, 82 (11): 1709-1714.

Tellinghuisen J. Optimizing experimental parameters in isothermal titration calorimetry. Journal of Physical Chemistry B. 2005, 109 (42): 20027-20035.

Tellinghuisen J. Understanding least squares through Monte Carlo calculations. Journal of Chemical Education. 2005, 82 (1): 157-166.

Tellinghuisen J. Global least-squares analysis of the IR rotation-vibration spectrum of HCl. Journal of Chemical Education. 2005, 82 (1): 150-156.

Tellinghuisen J. Simple algorithms for nonlinear calibration by the classical and standard additions methods. Analyst. 2005, 130 (3): 370-378.

Tellinghuisen J. Statistical error in isothermal titration calorimetry: Variance function estimation from generalized least squares. Analytical Biochemistry. 2005, 343 (1): 106-115.

Tellinghuisen J. Volume errors in isothermal titration calorimetry. Analytical Biochemistry. 2004, 333 (2): 405-406.

Specialties

• Physical Chemistry
• Chemometrics
• Chemical Physics

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